CHRONIC MUSCLE WEAKNESS AND MITOCHONDRIAL DYSFUNCTION IN THE ABSENCE OF SUSTAINED ATROPHY IN A PRECLINICAL SEPSIS MODEL

Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model

Chronic critical illness is a global clinical issue affecting millions of sepsis survivors annually.Survivors report chronic skeletal muscle weakness and development of new functional limitations that persist for years.To delineate mechanisms of sepsis-induced chronic weakness, we first surpassed a critical Parts Washer barrier by establishing a mu

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Multiple aspects of ATP-dependent nucleosome translocation by RSC and Mi-2 are directed by the underlying DNA sequence.

BACKGROUND:Chromosome structure, DNA metabolic processes and cell type identity can all be affected by changing the positions of nucleosomes along chromosomal DNA, a reaction that is catalysed by SNF2-type ATP-driven chromatin remodelers.Recently it was suggested that in vivo, more than 50% of the nucleosome positions can be predicted simply by Wom

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